Using memory recall response time on digital cognitive testing to detect subtle cognitive changes among cognitively unimpaired older adults.

ABSTRACT:

Introduction

We investigated whether memory recall response time (RT) on remote digital testing reflects decrements in memory function linked to Alzheimer's disease (AD) biomarkers.

Methods

One hundred seventy-five cognitively unimpaired participants (age = 74.21 ± 8.33; 66.9% female) completed daily associative memory tests over 7 days. We examined how RT changed with repeated learning and how this related to accuracy. In a positron emission tomography-imaged subsample (n = 150), linear regression evaluated associations between mean RT across Days 1 to 3 and Days 5 to 7 and cortical amyloid and medial temporal and neocortical tau.

Results

RT for correct items progressively decreased, with a stronger RT-accuracy association observed on later learning days than at base

SUBMITTER: Kim H 

PROVIDER: S-EPMC12568383 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature