Glymphatic and meningeal lymphatic dysfunction in Alzheimer's disease: Mechanisms and therapeutic perspectives.

ABSTRACT: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by amyloid-beta (Aβ) deposition and tau pathology. Although disease-modifying therapies, such as anti-Aβ monoclonal antibodies, have been approved, their clinical efficacy remains modest and accompanied by substantial safety concerns. The glymphatic system, which is a brain-wide waste clearance network mediated by cerebrospinal fluid-interstitial fluid exchange, is critical in AD pathogenesis. Glymphatic dysfunction promotes Aβ and tau accumulation, neuroinflammation, and vascular impairment, forming a vicious cycle that drives neurodegeneration. This review elucidates the anatomical and physiological basis of the glymphatic system, its role in AD progression, and novel therapeutic strategies targeting glymphatic enhanc

SUBMITTER: Ding J 

PROVIDER: S-EPMC12568399 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature