The integrated analysis of SIRT family expression, prognostic value, and potential implications in childhood acute lymphoblastic leukemia.

ABSTRACT:

Background

Acute lymphoblastic leukemia (ALL) is a rapidly progressive hematological malignancy caused by the dysregulated proliferation and abnormal differentiation or differentiation block of lymphoid precursors. The sirtuin family, as a highly conserved class of protein deacetylases dependent on NAD⁺, has been widely reported in leukemia. However, there has been no research on the prognostic value and molecular functions of the sirtuin protein family in pediatric ALL.

Methods

In this study, we employed the Therapeutically Applicable Research to Generate Effective Treatments (TARGET), Genotype-Tissue Expression (GTEx), Encyclopedia of RNA Interactomes (ENCORI), Cancer Therapeutics Response Portal (CTRP), and STRING databases as well as R language to explore and

SUBMITTER: Xu X 

PROVIDER: S-EPMC12568422 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature