Efficacy and Safety of iLet Bionic Pancreas in Patients With Type 1 Diabetes Mellitus: A Systematic Review and Meta Analysis.

ABSTRACT:

Background

This systematic review and meta-analysis evaluated the efficacy and safety of the iLet bionic pancreas (iLet BP), a novel automated insulin delivery (AID) system, in managing type 1 diabetes. Unlike conventional AID systems, which require user input for insulin dosing, the iLet BP autonomously determines insulin delivery based solely on body weight. The study synthesized data from five randomized controlled trials (RCTs), comprising a total of 1130 patients, comparing iLet BP with standard care (SC).

Outcomes assessed

Primary outcomes included changes in HbA1c, mean glucose levels, and time in target glucose range (70-180 mg/dL), measured via continuous glucose monitoring (CGM). Secondary outcomes assessed adverse events and hypoglycaemia.

Key findings

Resu

SUBMITTER: Kumar S 

PROVIDER: S-EPMC12568523 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature