Does Aspirin Use Influence Rates of Pseudoarthrosis After Anterior Cervical Discectomy and Fusion?

ABSTRACT: Study DesignRetrospective propensity-matched cohort study.ObjectivesAspirin's role in bone remodeling after spinal fusion is unclear. We evaluated the relationship between aspirin use and pseudoarthrosis after ACDF surgery.MethodsData was collected from TriNetX, a large research platform including 67 participating healthcare organizations, to identify single- and multi-level ACDF cohorts stratified by no aspirin, aspirin 81 mg and 325 mg daily use. The primary outcome was diagnosis of pseudoarthrosis. Propensity score matching (1:1 ratio) was performed for demographic/clinical variables, followed by risk analyses to determine odds of outcome at 6-months, 1-year, and 2-years. Reoperation rate (additional spinal fusion) was assessed for cohorts with significant results.ResultsThere were sign

SUBMITTER: Kim KT 

PROVIDER: S-EPMC12568543 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature