Artificial cell vesicle-mediated delivery of <i>Catharanthus roseus</i> (L.) G. Don-derived vinca alkaloids for enhanced antitumor efficacy.

ABSTRACT: Vinca alkaloids, a class of naturally derived antimitotic agents isolated from Catharanthus roseus, have long been established as potent chemotherapeutic drugs for the treatment of various malignancies. Despite their clinical efficacy, the therapeutic utility of vinca alkaloids, such as vincristine, vinblastine, and vinorelbine, is frequently constrained by systemic toxicity, poor bioavailability, and the emergence of multidrug resistance. In this study, we developed a universal strategy to construct cell membrane-derived vesicles for the encapsulation of vinca alkaloids, thereby enhancing their antitumor efficacy. These artificial cell vesicles were fabricated through the extraction and reconstitution of membranes from K562 cells. Following optimization of drug-loading efficiency,

SUBMITTER: Zhuang X 

PROVIDER: S-EPMC12568567 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature