A six-gene expression signature in peripheral blood mononuclear cells effectively diagnoses osteoarthritis.

ABSTRACT:

Introduction

Osteoarthritis (OA) is a heterogeneous whole-joint disease that inconveniences more than 500 million people worldwide. Early diagnostic methods for OA remain lacking. Peripheral blood mononuclear cells (PBMCs) are ideal sample sources for the early diagnosis of different diseases. However, only a few studies have reported on the role of PBMCs in the early diagnosis of OA.

Methods

RNA sequencing was performed on PBMC samples from 27 patients with OA and 31 healthy controls. We integrated RNA sequencing data from our internal cohort and microarray data from external cohort to construct a diagnostic model of OA based on PBMC samples. The receiver operating characteristic (ROC) curve analysis was used to evaluate the diagnostic model in PBMC samples and synovial tis

SUBMITTER: Yu D 

PROVIDER: S-EPMC12568575 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature