Uncovering the potential of Yiqi Huoxue Jiedu formula: a promising adjunct in sepsis and septic shock management.

ABSTRACT:

Background

Sepsis and septic shock represent severe infectious conditions with challenging treatments. Preliminary animal studies indicate that Yiqi Huoxue Jiedu Formula (YHJF) may enhance sepsis outcomes, but no clinical trials have been conducted. This research aims to substantiate the efficacy of YHJF in treating sepsis and septic shock.

Materials and methods

Mass spectrometry was used to identify the absorbed constituents of YHJF. A retrospective cohort study included sepsis patients from four sub-centers (Feb 24, 2016 - Oct 31, 2024), divided into Western treatment and YHJF plus Western care groups. Propensity score matching ensured baseline comparability. The primary outcome was 28-day mortality, with secondary outcomes including intensive care units (ICU) and hospital

SUBMITTER: Huang P 

PROVIDER: S-EPMC12568585 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature