Prognostic value of presepsin in sepsis and septic shock: a meta-analysis.

ABSTRACT:

Background

Presepsin, an innate immune activation biomarker, shows potential for predicting the prognosis of sepsis, but its predictive accuracy remains unclear. This meta-analysis aims to evaluate its efficiency for predicting the risk of mortality in sepsis and septic shock.

Methods

Per PRISMA guidelines, four databases were searched until January 2025. Sixteen observational studies with 2,066 patients were included. Pooled sensitivity, specificity, DOR, and AUC were calculated using bivariate random-effects models. The sources of heterogeneity were explored via subgroup analyses and meta-regression. Study quality was assessed with QUADAS-2.

Results

Presepsin showed moderate accuracy for predicting the risk of mortality (pooled AUC 0.80, 95% CI: 0.76-0.83). The pool

SUBMITTER: Xing X 

PROVIDER: S-EPMC12568590 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature