Increasing arterial compliance by laser modification of fibro-calcific plaques.

ABSTRACT:

Background

Calcium is a constituent of numerous types of atherosclerotic plaques. While various vessel modification devices have been introduced, plaque heterogeneity presents a challenge to direct therapy to specific components within the arterial wall.

Aims

We introduce a novel approach for non-destructive modification of arterial fibrocalcific plaques with controlled spatial-temporal diode-laser irradiation. The laser thermomechanical approach enables the controlled formation of microstructural defects, stress relaxation, microcracking, and plaque molding. Primary objectives of this exploratory study include: (1) Determine an optimal laser dosimetry in fibro-calcific plaques in ex vivo human arteries that mitigates against non-specific thermal injury of the vessel

SUBMITTER: Rajebahadur S 

PROVIDER: S-EPMC12568616 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature