Comprehensive analysis of m6A methylated modification of fibrotic atria in rats induced by chronic intermittent hypoxia.

ABSTRACT:

Background

Atrial fibrosis serves as a key pathological basis for atrial fibrillation, significantly elevating the risk of cardiovascular events. However, its molecular mechanisms remain incompletely understood. N⁶-methyladenosine (m6A) modifications have been proven to involve in the pathological processes of cardiovascular diseases, yet its role in atrial fibrosis remains unclear. m6A plays an important role in disease pathogenesis via mRNA modification. This study aimed to define the role of m6A modifications in the fibrotic atria of rats with chronic intermittent hypoxia (CIH).

Methods

A CIH model was established using rats living in an intermittent hypoxia simulation chamber filled with oxygen and nitrogen. Myocardial function and atrial fibrosis were examined by echoca

SUBMITTER: Geng T 

PROVIDER: S-EPMC12568672 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature