Genetic association and functional implications of AhR gene polymorphism on preeclampsia.

ABSTRACT:

Background

Preeclampsia is one of the main causes of increased maternal and infant mortality and morbidity during pregnancy. The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor ubiquitously found in mammals that can directly or indirectly regulate various physiological processes when activated.

Methods

In this case-control study, 74 patients with preeclampsia and 120 healthy pregnant controls were recruited. SNaPshot technology was used to detect genetic polymorphisms in four TagSNPs of the AhR gene. In addition, quantitative real-time PCR and western blotting were used to detect the expression of AhR in placental tissues from 21 patients with preeclampsia and 20 healthy controls. Subsequently, siRNA and drug treatment were used in vitro stu

SUBMITTER: Jiang H 

PROVIDER: S-EPMC12568678 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature