Histologically confirmed high-grade cervical intraepithelial neoplasia successfully treated with topical Paiteling: a two-case report.

ABSTRACT:

Background

High-grade cervical intraepithelial neoplasia (HSIL) threatens fertility-aged women worldwide. Surgical excision remains standard but may compromise future pregnancy. Paiteling, a multi-herbal topical preparation, has shown in vitro anti-HPV activity, yet clinical evidence is scant.

Case presentation

Two reproductive-aged women with biopsy-proven HSIL refused loop electrosurgical excision. Biopsy slides were re-reviewed independently with p16 and Ki-67 immunostaining. Case 1 was CIN II and Case 2 was CIN III. Both patients received topical Paiteling (0.5 mL/lesion, three times weekly) plus 1% vaginal douche for 10 weeks.

Intervention & outcome

Lesions regressed completely within the treatment course. HPV-DNA testing confirmed HPV clearance by week 12

SUBMITTER: Li J 

PROVIDER: S-EPMC12568692 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature