Device-based day-to-day and observer variability to quantify dilation capacity in the retinal microcirculation.

ABSTRACT:

Introduction

Dynamic retinal analysis (DVA) is a validated method to quantify microvascular endothelial function. This study aimed to analyze day-to-day variability, intra- and interobserver variability and differences between two device generations.

Methods

DVA was performed on two separate days and on two devices each, the DVA 2.0 and the DVA 3.0. One reader analyzed 20 signals of maximum arteriolar (aFID) and venular flicker-light induced dilation (vFID) twice to investigate intraobserver variability. A second reader independently analyzed 20 aFID and vFID signals to quantify interobserver variability. The interclass correlation coefficient (ICC) and the 95% confidence interval were used to quantify reliability.

Results

The analysis of 26 participants (mean age 43

SUBMITTER: Streese L 

PROVIDER: S-EPMC12568701 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature