Comparative immunophenotyping of peripheral blood lymphocyte subsets in pulmonary tuberculosis and nontuberculous mycobacterial pulmonary disease: a retrospective study.

ABSTRACT:

Objective

To compare peripheral blood lymphocyte profiles between pulmonary tuberculosis (PTB) and nontuberculous mycobacterial pulmonary disease (NTMPD) patients and explore whether these immunophenotypic differences may assist future diagnostic algorithms.

Methods

This retrospective study analyzed clinical data of 78 PTB patients, 73 NTMPD patients, and 80 healthy controls from the Shanghai Public Health Clinical Center between February 2024 and February 2025. Peripheral blood lymphocyte subsets were measured using flow cytometry. Logistic regression and receiver operating characteristic (ROC) curve analyses were performed to identify and assess diagnostic markers.

Results

No significant differences in age or body mass index (BMI) were found among the three groups (

SUBMITTER: Ren S 

PROVIDER: S-EPMC12568706 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature