Multiomics profiling reveals that <i>P. gingivalis</i>-induced extracellular vesicle reprogramming promotes immune evasion in colorectal cancer through autophagy-mediated STING degradation.

ABSTRACT:

Objective

Porphyromonas gingivalis (P. gingivalis) infection is a recognized pathogenic factor in colorectal cancer (CRC), and extracellular vesicles (EVs) are key mediators within the tumor microenvironment. However, the molecular composition of large extracellular vesicles (lEVs) derived from P. gingivalis-infected cancer cells remains poorly characterized. This study aimed to comprehensively define the molecular cargo alterations in lEVs secreted by CRC cells in response to P. gingivalis infection.

Methods

An integrated multiomics approach was employed to analyze lEVs secreted by P. gingivalis-infected HCT116 colorectal cancer cells. miRNA sequencing and quantitative proteomics were used to profile miRNA and protein expression, respectiv

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12568708 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature