Ovarian lipid metabolic alterations in polycystic ovary syndrome: insights from proton magnetic resonance spectroscopy.

ABSTRACT:

Objectives

Altered ovarian lipid metabolism plays a critical role in the pathophysiology of polycystic ovary syndrome (PCOS). This study aimed to evaluate and compare ovarian lipid metabolic profiles in PCOS patients and healthy controls using proton magnetic resonance spectroscopy (¹H-MRS).

Method

This was a single-center prospective study. Single-voxel ¹H-MRS was used to identify the lipid metabolism in 50 PCOS patients and 40 healthy controls (training cohort). A total of 34 PCOS patients and 39 controls underwent ¹H-MRS on the contralateral ovaries (test cohort). Key lipid metabolites were identified and quantified using LCModel software. A combination of these key lipids using the binary logistic regression analysis was constructed to en

SUBMITTER: Wang KY 

PROVIDER: S-EPMC12568718 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature