Improved 5-year survival with robot-assisted resection for locally advanced rectal cancer compared to laparoscopic and open surgery: A real-world cohort study.

ABSTRACT:

Aim

Robot-assisted rectal cancer surgery offers short-term benefits; however, data on its long-term outcomes are lacking. In this study, we aimed to compare the short- and long-term outcomes of open, laparoscopic and robot-assisted rectal resection (ORR, LRR and RARR) for locally advanced rectal cancer using a large real-world database.

Methods

This multi-centre retrospective cohort study analysed 37,191 patients with clinical T3/T4a rectal cancer from the Japanese Medical Data Vision database (2018-2024). After overlap weighting for baseline balance, the effective sample size was 14,627. The primary outcomes were 5-year overall survival (OS) and relapse-free survival (RFS). The secondary outcomes included peri-operative outcomes.

Results

After overlap weighting, the

SUBMITTER: Hanaoka M 

PROVIDER: S-EPMC12568752 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature