DNase Activity of Prevotella intermedia Impairs Biofilm Development and Neutrophil Extracellular Trap Formation.

ABSTRACT: Chronic periodotitis is caused by the formation of biofilms. Prevotella intermedia, a gram-negative obligate anaerobic bacterium residing in periodontal pockets is involved in the formation of biofilms and secrets a highly potent DNA-degrading activity. Biofilm contains extracellular DNA as a structural component, suggesting that DNase activity may influence P. intermedia's own biofilm development. Neutrophil extracellular traps (NETs) have mesh-like structures and composed of DNA, histone and antibacterial proteins. NETs play an important role in protecting against infection, but it is possible that DNase of P. intermedia disrupts NETs. The lack of established genetic manipulation has significantly delayed the analysis of DNase pathogenic factors. Recently, we have succeeded in establishi

SUBMITTER: Seto-Tetsuo F 

PROVIDER: S-EPMC12568770 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature