Genetically Engineered Yeast for Enhanced Biodegradation of Β-lactam Antibiotics.

ABSTRACT: High environmental concentrations of pharmaceuticals, particularly antibiotics, have been observed worldwide, while antibiotic concentrations in the ng/L to µg/L range may adversely affect biota and contribute to the formation of antibiotic resistance. The underlying causes of high environmental concentrations include, in addition to the low rate of antibiotic' metabolization and the high rate of usage, especially of β-lactam antibiotics, the insufficient removal by conventional wastewater treatment methods. Consequently, alternative methods need to be developed to remove antibiotics from wastewater-one possibility is the use of enzymes. In this study, the enzyme β-lactamase was secreted by a genetically modified yeast (Saccharomyces cerevisiae) upon recognition of a pheromone (α-factor) a

SUBMITTER: Pohl C 

PROVIDER: S-EPMC12568803 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature