Low skeletal muscle index combined with reduced bone density increases mortality rate in older adults with heart failure.

ABSTRACT:

Background

Heart failure (HF) is associated with high mortality and poor prognosis in older adults. Reduced skeletal muscle mass and low bone mineral density are prevalent comorbidities in this population; however, their combined impact on clinical outcomes remains underexplored. AMIS: This study aimed to investigate the prognostic impact of reduced skeletal muscle mass and bone mineral density in older adults with HF.

Methods and results

In this retrospective, single-center cohort study, 412 older HF patients (aged ≥ 60 years) were classified into four groups based on thoracic CT-derived vertebral bone density (VBD) and skeletal muscle index (SMI): normal VBD and SMI, low SMI alone, low VBD alone, and combined low VBD and SMI. All-cause mortality was assessed over a median

SUBMITTER: Wang Q 

PROVIDER: S-EPMC12568808 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature