β-tricalcium phosphate/gelatin composite scaffolds incorporated with gentamycin-loaded chitosan microspheres for periodontal regeneration in class II furcation defects in dogs.

ABSTRACT:

Objectives

The present study aimed to evaluate the effect of β-tricalcium phosphate/gelatin composite scaffolds incorporated with gentamycin-loaded chitosan microspheres for periodontal regeneration in Class II Furcation Defects in Dogs.

Materials and methods

24 bilateral class II furcation defects, 5 mm height, and 3 mm depth, were surgically created on the buccal surface of mandibular premolars and allowed to become chronically healed in six mongrel male dogs. Dogs were randomly divided into three groups: Group I received β-tricalcium phosphate/gelatin composite scaffolds incorporated with gentamycin-loaded chitosan microspheres (CMs (GM)-β-TCP/gelatin composite scaffolds). Group II received the same scaffolds without gentamycin. Group III received open flap debridement (O

SUBMITTER: Helal MH 

PROVIDER: S-EPMC12568831 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature