An in-depth characterization of development-related electroretinographical and morphological changes in Landrace pigs.

ABSTRACT:

Purpose

Landrace pigs are increasingly used as a large-animal model in ophthalmic research due to their cone-enriched visual streak and anatomical similarity to the human eye. However, they are commonly studied at 16-20 weeks of age, a timeframe in which the animals double their weight and development-related physiological changes may occur. This study aims to characterize retinal function and morphology and establish reference values for future translational studies.

Methods

Landrace pigs (16-20 weeks old) underwent standardized examinations of the left eye at baseline (16 weeks), 18 and 20 weeks. The left eye was examined by optical coherence tomography (OCT), fundus photography, histology, and full-field electroretinography (ffERG) under light- and dark-adapted conditions

SUBMITTER: Skrzypczyk L 

PROVIDER: S-EPMC12568845 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature