The mesopic negative response (MeNR): a novel approach to assess retinal ganglion cell function within the rod pathway.

ABSTRACT:

Purpose

The photopic negative response (PhNR) and pattern ERG, both established electrophysiological measures of retinal ganglion cell (RGC) function, are recorded under photopic conditions. The purpose of this study was to describe the mesopic negative response (MeNR), a novel marker of RGC function within the rod pathway.

Methods

Ten visually-normal controls (mean age ± SD 54.6 ± 5.6 years) and 12 patients with severe primary open-angle glaucoma (mean age ± SD 58.4 ± 4.9 years) participated. Light-adapted, full-field ERGs were elicited by a rod-isolating pulse generated on the principle of silent substitution (0.46 scot. cd/m²; 55% contrast; 40 ms) presented against a steady background (0.30 scot. cd/m²). In addition, (1) the PhNR was recorded; (2) su

SUBMITTER: McAnany JJ 

PROVIDER: S-EPMC12568855 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature