A core outcome set for locoregional treatment reporting in neoadjuvant systemic breast cancer treatment trials.

ABSTRACT: Accurate information about locoregional breast cancer treatments following neoadjuvant systemic therapy (NST) is essential for meaningful interpretation of oncological outcomes but reporting is currently poor. We developed a core outcome set (COS) to improve the quality and consistency of locoregional outcome reporting in breast cancer NST trials. The COS was developed in three phases according to COS-STAD guidance, with the generation of a list of relevant outcome domains, prioritisation of outcomes through two rounds of an international online multi-stakeholder Delphi survey and a consensus meeting. 159 unique locoregional outcomes were classified into 101 outcome domains for inclusion in the Delphi survey, which was completed by 470 international professionals. The final 15-item COS, wh

SUBMITTER: Potter S 

PROVIDER: S-EPMC12568921 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature