Circulating vascular biomarkers in relation to physiological indices of aortic stiffness and endothelial function in hypertension.

ABSTRACT: Studies investigating the relation between circulating vascular biomarkers reflecting endothelial dysfunction and physiological methods to evaluate vascular function remain limited. We simultaneously evaluated the relation between circulating endothelial biomarkers with physiological non-invasive vascular methods in 107 hypertensive patients with a wide range of mean estimated glomerular filtration rate (eGFR). Endothelial glycocalyx hyaluronan (HA) and syndecan-1 (SDC-1), and cellular adhesion molecules (ICAM-1, VCAM-1, and E-selectin) were measured by enzyme-linked immunosorbent assays. Aortic stiffness (cfPWV) was assessed by pulse wave analysis. Endothelial function in different vascular beds was evaluated physiological by methods: flow mediated vasodilation (large arteries), pulse wav

SUBMITTER: Jekell A 

PROVIDER: S-EPMC12568971 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature