Genomic insights into biosynthetic gene cluster diversity and structural variability in marine bacteria.

ABSTRACT: Marine bacteria are a rich source of bioactive compounds, many of which are encoded by biosynthetic gene clusters (BGCs). Understanding the diversity and structural variability of these clusters can provide insights into novel natural product discovery. This study analyzed 199 marine bacterial genomes from 21 species, screening for BGCs using antiSMASH 7.0. Phylogenetic relationships were assessed using rpoB gene-based analysis, and BGC clustering was performed using BiG-SCAPE. The study focused on NI-siderophore BGCs encoding vibrioferrin, assessing genetic and structural variations across Vibrio harveyi, Vibrio alginolyticus, and Photobacterium damselae. A total of 29 BGC types were identified, with non-ribosomal peptide synthetases (NRPS), betalactone, and NI-siderophores being predomin

SUBMITTER: Al-Siyabi N 

PROVIDER: S-EPMC12569011 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature