Effect of gamma irradiation on the Cu(II), Ru(III) and Pd(II) complexes of azo antipyrine moiety and their biological applications.

ABSTRACT: Three novel Cu(II), Ru(III), and Pd(II) chelates of the ligand N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)carbonohydrazonoyl dicyanide (HL) were synthesized and fully characterized using IR, NMR, elemental analysis, molar conductivity, melting point, mass spectra, electronic spectra, PXRD, and thermal analysis. Geometry optimization with Gaussian09 confirmed the structures: [Cu(HL)Cl(OH)].H₂O (B1), [Ru(HL)Cl₂(OH)(H₂O)].H₂O (B2), and [Pd(HL)Cl₂].2H₂O (B3). The antibacterial and anticancer activities of non-irradiated and γ-irradiated complexes were evaluated against multiple bacterial strains and the MCF-7 breast cancer cell line. The results demonstrated that most of the tested compounds possess broad-spectru

SUBMITTER: Abdalla EM 

PROVIDER: S-EPMC12569019 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature