Villin like suppresses nasopharyngeal carcinoma proliferation by downregulating MYC.

ABSTRACT: The initial manifestations of nasopharyngeal carcinoma (NPC) are subtle and imperceptible, leading to unfavorable clinical outcomes and limited therapeutic alternatives among Southeast Asian populations. Deletion of chromosome 3p is a commonly observed genetic alteration in NPC. In our endeavor to elucidate the key genes and pathways driving NPC growth, we have discovered that Villin like (VILL), located at 3p22.2, functions as a novel tumor suppressor gene (TSG) with significantly diminished expression levels in NPC. This finding underscores the tremendous potential of VILL as an unexplored molecule warranting further investigation. Overexpressing VILL effectively inhibits proliferation by inducing G1 phase arrest in NPC cells while its knockdown yields contrasting effects on cell growth

SUBMITTER: Wen Y 

PROVIDER: S-EPMC12569157 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature