Impact of meditation on brain age derived from multimodal neuroimaging in experts and older adults from a randomized trial.

ABSTRACT: Meditation is thought to promote healthy aging by improving mental health, preserving brain integrity and reducing Alzheimer's disease risk. We examined the impact of long-term meditation expertise and an 18-month meditation training on brain aging in older adults using machine learning. We included 25 Older Expert Meditators (OldExpMed) with > 20 years of practice and 135 Cognitively Unimpaired Older Adults (CUOA) from the Age-Well randomized controlled trial. CUOA were randomized (1:1:1) into an 18-month meditation training, a non-native language training, and a no intervention group. Brain age was predicted using a machine learning model trained on gray and white matter volume and glucose metabolism data from ADNI and replicated with a second model. Brain Predicted Age Difference (Brain

SUBMITTER: Haudry S 

PROVIDER: S-EPMC12569194 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature