[¹¹C]Fentanyl: radiosynthesis and preclinical pet imaging for its pharmacokinetics.

ABSTRACT:

Background

Fentanyl is a potent synthetic opioid widely used for pain management and anesthesia, but the high prevalence of its misuse and its key contribution to overdose fatalities in the United States have made it a major drug of concern. Although fentanyl's onset, duration, and toxicity depend on its pharmacokinetics and specific tissue distribution, most studies have focused primarily on plasma concentrations, leaving its distribution in critical tissues largely unexplored (this knowledge gap limits our understanding of fentanyl's clinical effects, tissue accumulation, and the factors influencing its efficacy and safety). Here, we report the radiosynthesis of [¹¹C]fentanyl for PET imaging and present a preliminary whole-body pharmacokinetic study in rodents.

Resu

SUBMITTER: Kim W 

PROVIDER: S-EPMC12569255 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature