ENcyclopedia of TRAnscription Factors in Bacteria and Archaea genomes (ENTRAF) version 2.0.

ABSTRACT: DNA-binding transcription factors (TFs) have a central role in regulation of gene expression at the transcription initiation level. These proteins have been experimentally described in multiple bacterial and archaeal genomes. These descriptions have allowed their prediction in complete genomes. In this work, we collected 1784 experimentally validated TFs across 25 bacterial and seven archaeal phyla, including Gammaproteobacteria, Bacillota, and Actinomycetota in bacteria and Thermoproteota and Thermococci in archaea. The collection of regulatory proteins was organized into a relational database, named ENcyclopedia of TRAnscription Factors in Bacteria and Archaea genomes or ENTRAF. The database shows the experimental evidence for all the TFs [protein structure information (X-ray or NMR stru

SUBMITTER: Tenorio-Salgado S 

PROVIDER: S-EPMC12569306 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature