Integrative analysis of single-cell and transcriptome RNA sequencing to establish a NAT10-related signature for prognostic prediction of uveal melanoma.

ABSTRACT: Uveal melanoma (UVM), an intraocular malignant tumor originating from uveal melanocytes, not only induces blindness but also exhibits a high fatality risk. Despite the emergence of numerous local treatment modalities for UM in recent years, such as brachytherapy and proton beam radiotherapy, the prognosis of this disease remains suboptimal. RNA modification, which pertains to diverse chemical modifications on RNA molecules, plays a pivotal role in modulating gene expression and maintaining cell functions. N-acetyltransferase 10 (NAT10), the first reported mRNA acetylation regulator, can be activated in various cancers. However, the function of NAT10 in UVM remains elusive. In the present study, by integrating the gene expression information and clinical data from the TCGA database, we empl

SUBMITTER: Liu W 

PROVIDER: S-EPMC12569318 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature