Visceral adipose tissue accumulation and risk of organ complications among individuals with type 2 diabetes mellitus: A two-sample Mendelian randomization study.

ABSTRACT: Visceral adiposity is a pivotal pathogenic driver of type 2 diabetes mellitus (T2DM) and its vascular complications. We performed two-sample Mendelian randomization (MR) analyses to examine the causal relationships between visceral adipose tissue (VAT) accumulation and diabetes complications. Single nucleotide polymorphisms (SNPs) specific to VAT accumulation were identified through large-scale genome-wide association studies (GWAS) at genome-wide significance (P < 5 × 10^-8), using the inverse variance weighted (IVW) approach for primary analyses. The MR-IVW random-effects model revealed significant associations between genetically predicted VAT accumulation and increased risks for T2DM complications: multi-organ (OR = 2.58, 95% CI, 2.21-3.03), neurological (OR = 3.58, 95

SUBMITTER: Lian X 

PROVIDER: S-EPMC12569360 | biostudies-literature | 2025 Sep-Oct

REPOSITORIES: biostudies-literature