Equivalent-Uniform-Dose Optimization for Spatially Fractionated Radiation Therapy.

ABSTRACT: BackgroundSpatially fractionated radiotherapy (SFRT) intentionally creates spatially-modulated peak-valley dose patterns for improving the tumor control or/and the sparing of organs at risk, compared to conventional radiotherapy (CONV). Evaluating non-uniform dose distributions using conventional physical dose does not fully account for the biological effectiveness of SFRT. In this study, we adopt the equivalent uniform dose (EUD) as a surrogate metric to evaluate non-uniform dose distributions.PurposeThis work will develop a SFRT treatment planning method with EUD optimization, which is the first-of-its-kind to the best of our knowledge.MethodsThe SFRT scenario of proton GRID with uniform target dose is considered in this work for dose-only optimization (DO) and joint dose and peak-valley

SUBMITTER: Zhu YN 

PROVIDER: S-EPMC12569369 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature