LLTH induces white adipose tissue browning via NF κB inhibition in ATM.

ABSTRACT: This study aimed to explore the role of macrophage polarization and TLR4/NF-κB pathway in promoting browning of white adipose tissue through different hypoxic exercises. (1) Fifty obese female rats were selected after 16 weeks of high-fat diet feeding and randomly divided into normoxic sedentary (NC), normoxic exercise (NE), hypoxic sedentary (HC), Living-High Training-High (HH), and Living-Low Training-High (LH) groups. Four weeks of hypoxic and exercise interventions were conducted to investigate changes in the expression of the TLR4/NF-κB pathway and inflammatory factors in obese rat adipose tissue and the expression of genes and proteins related to adipose tissue browning. (2) After the 4-week intervention, adipose tissue macrophages (ATM) were isolated from HH and LH groups, activated

SUBMITTER: Lu Y 

PROVIDER: S-EPMC12569381 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature