Efficacy and safety of live combined <i>Bacillus subtilis</i> and <i>Enterococcus faecium</i> in patients with constipation: a meta-analysis of randomized controlled trials.

ABSTRACT:

Background

Live combined Bacillus subtilis and Enterococcus faecium (LCBE) provides favorable clinical benefits in patients with constipation, although a comprehensive evaluation is lacking. This meta-analysis aimed to thoroughly evaluate the efficacy and safety of LCBE in patients with constipation.

Methods

Randomized controlled trials (RCTs) assessing the efficacy or safety of LCBE in patients with constipation, published before September 2025, were comprehensively searched for in Wan Fang, China National Knowledge Infrastructure, China Science and Technology Journal Database, Web of Science, Cochrane Library, and PubMed. Efficacy and safety outcomes were extracted.

Results

A total of 32 studies were included, containing 1,565 patients receiving LCBE a

SUBMITTER: Li W 

PROVIDER: S-EPMC12569391 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature