Early Anticoagulation After Large Ischemic Stroke in the Initiation of Anticoagulation After Cardioembolic Stroke Study.

ABSTRACT:

Background and purpose

Clinical trial data indicate that early anticoagulation is generally safe after an ischemic stroke, but there is a paucity of real-world data regarding the safety of early initiation in large strokes. We sought to determine the association between the time to the initiation of anticoagulation and the 90-day risk of recurrent ischemic and major hemorrhagic events.

Methods

We analyzed consecutive patients with an acute large ischemic stroke (volume ≥60 mL) who were included in the multicenter Initiation of Anticoagulation After Cardioembolic Stroke (IAC) study. We assessed recurrent ischemic events (transient ischemic attack, ischemic stroke, and systemic embolism), major hemorrhagic events (symptomatic intracranial hemorrhage [sICH] and major extracrani

SUBMITTER: Muppa J 

PROVIDER: S-EPMC12569412 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature