Efficacy of a Smartphone-Based Digital Therapeutic (Anzeilax) in Generalized Anxiety Disorder: Randomized Controlled Trial.

ABSTRACT:

Background

Individuals with generalized anxiety disorder (GAD) often face challenges with self-regulation and limited access to traditional therapy. Although acceptance and commitment therapy (ACT) has demonstrated both efficacy and effectiveness in promoting psychological flexibility, scalable solutions are necessary to address these barriers. This study introduces Anzeilax, an ACT-based digital therapeutic (DTx) that incorporates self-talk as a novel mechanism of action (MoA) to enhance psychological flexibility in the treatment of GAD.

Objective

This study aimed to evaluate the efficacy of Anzeilax in reducing anxiety symptoms in individuals with GAD.

Methods

A 10-week, parallel-group, superiority randomized controlled trial (RCT) was conducted with 96 participants

SUBMITTER: Park C 

PROVIDER: S-EPMC12569493 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature