Protective Effect and Immune Mechanism of EPCP009 Booster Immunization after BCG Prime Immunization Against Tuberculosis in Mice - China, 2024.

ABSTRACT:

What is already known about this topic?

At present, relatively few theoretical studies exist on the immunization strategies of tuberculosis vaccines, especially regarding the types of subunit protein vaccines suitable for combined application with Bacillus Calmette-Guérin (BCG).

What is added by this report?

The study demonstrated that EPCP009, a novel subunit vaccine candidate, maintains BCG colonization in murine spleens while enhancing protection. Notably, a single dose of EPCP009 combined with BCG was superior to multiple doses in terms of both short-term (6-week) and long-term (12-week) protection.

What are the implications for public health practice?

These studies provide a theoretical basis for enhancing the immune strategy of tuberculosis vaccines and contribu

SUBMITTER: Wang R 

PROVIDER: S-EPMC12569536 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature