Genomic Characterization of Human Adenovirus Type 21 Strains - 7 PLADs, China, 2023-2024.

ABSTRACT:

Introduction

Recent sentinel surveillance has revealed a rising prevalence of human adenovirus type 21 (HAdV-21) among HAdV infections in China. This study aimed to elucidate the molecular features of currently circulating HAdV-21 strains in China.

Methods

Whole-genome sequencing (WGS) was performed on 23 HAdV-21 strains isolated from acute respiratory infection cases, 56.5% involving lower respiratory tract infections, across 7 Chinese sentinel surveillance provincial-level administrative divisions (PLADs) (2023-2024). These sequences, along with 50 previously reported HAdV-21 genomes from 6 countries (1956-2019), were integrated into a WGS dataset for comprehensive phylogenetic, genetic variation, and recombination analyses.

Results

WGS categorized the HAdV-21 strai

SUBMITTER: Jin Y 

PROVIDER: S-EPMC12569540 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature