Cefuroxime axetil dosing regimens and probability of target attainment in adults and children.

ABSTRACT:

Aims

Cefuroxime axetil exists in several dosage forms for oral administration, and is indicated for treatment of respiratory, genitourinary, skin and soft tissue infections. Evolving patterns of bacterial susceptibility, expressed as increasing minimum inhibitory concentrations (MICs), warrant monitoring of antibiotic efficacy. Here we investigate the performance of different cefuroxime axetil doses required to yield the desired target exposure against the predominant pathogens for each indication.

Methods

The pharmacokinetics of cefuroxime in plasma/serum and urine was characterized after oral, intravenous and intramuscular administration. Covariates included the effect of weight on clearance and volume of distribution, and formulation on absorption parameters. Subsequently

SUBMITTER: van Dijkman SC 

PROVIDER: S-EPMC12569549 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature