Probability of pharmacokinetic/pharmacodynamic target attainment for different piperacillin/tazobactam dosing regimens in renally impaired patients in a non-intensive care unit setting.

ABSTRACT:

Aims

To optimize antibiotic therapy for pathogens classified as susceptible, increased exposure (I), an increased exposure of piperacillin/tazobactam (PTZ) is required. However, dosing recommendations are currently only available for patients with normal renal function. The aim of the study was to assess whether the recommended dosages of PTZ for patients with impaired renal function achieve adequate pharmacokinetic/pharmacodynamic (PK/PD) targets for pathogens classified as susceptible, increased exposure (I).

Methods

Overall, 49 patients with impaired renal function were included in this study (estimated glomerular filtration rate [eGFR] 20-40 mL/min: n = 20; eGFR <20 mL/min: n = 19; intermittent haemodialysis: n = 10). Peak, trough and between-dosing interval piperacillin

SUBMITTER: Dohmann E 

PROVIDER: S-EPMC12569551 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature