The synergistic effect of anticholinergic burden and depression on fall risk in older persons.

ABSTRACT:

Aims

Both anticholinergic burden (ACB) and depression are known to increase fall risk in older persons, next to increasing morbidity and mortality. However, the effect of depression on fall risk associated with ACB is unclear. This is relevant because several antidepressants have anticholinergic effects to some extent. The aim of this study was to assess the relationship between ACB and falls, and the impact of depression on this relationship.

Methods

We cross-sectionally examined the relationship between both ACB and clinical depression and falls in the past 12 months, in a harmonized cohort of Dutch community dwelling persons (n = 7884). For all analyses, we calculated adjusted odds ratios (ORs) and their 95% confidence intervals (CI). We also investigated the impact of de

SUBMITTER: Salet R 

PROVIDER: S-EPMC12569557 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature