Amyloid and tau may moderate practice effects in semantic and episodic memory in a cognitively unimpaired at-risk sample.

ABSTRACT: Previous studies in pre-clinical Alzheimer's disease have found associations between amyloid and practice effects. Additionally, studies within our research group have found associations between practice effects and cognitive tests, including language-based measures, as well as associations between language-based measures and Alzheimer's disease biomarkers. The purpose of this study is to bridge the gaps between these areas to further understand how practice effects may or may not explain additional variance between biomarker groups and to expand on current literature by incorporating tau status into these models. Our study had three main aims: (1) determine which of our proposed operationalizations of practice effects performed best, (2) explore the impact of amyloid on practice effects a

SUBMITTER: Basche K 

PROVIDER: S-EPMC12569600 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature