<i>N</i>-Acetyltransferase 2 Inhibits Myopia by Maintaining Mitochondrial Metabolism in Scleral Fibroblasts.

ABSTRACT: The excessive elongation of eye axis is a primary contributing factor of myopia, yet the underlying genetic mechanisms remain not fully understood. The study was to explore risk-associated genes of myopia and identified that N-acetyltransferase 2 (NAT2) acted as a regulator in the pathological process of myopia. The genome-wide association study analysis was performed for axial length of eyes in a Chinese population aged 4 to 18 years (n = 6,345), and the most significant locus was 8p22, with NAT2 identified as a potential risk-associated gene for myopia. NAT2 was down-regulated by hypoxia in form deprivation-induced murine myopia, and the adeno-associated virus-induced genetic intervention of NAT2 in sclera influenced myopia progression. For mechanism, NAT2 could regu

SUBMITTER: Gong W 

PROVIDER: S-EPMC12569602 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature