Acid accumulation in bipolar disorder.

ABSTRACT: Acid accumulation (AA) describes the continuum of hydrogen ions concentration in the body reflected by increased acid-base buffer activity manifested by low bicarbonate (HCO3) concentration, increased anion gap (AG) or corrected AG (CAG). AA is associated with dietary acid-load, mitochondrial dysfunction, alcohol-abuse, obesity, hypertension, insulin resistance, and kidney disease. Despite these factors being highly prevalent in bipolar disorder (BD) AA has not been studied in this population. In this study we assessed AA in persons with BD and compared them primarily to controls and secondarily to individuals with BD and alcohol withdrawal syndrome (AWS). Available electronic health record data was analyzed from persons with BD (n = 733) enrolled in the Mayo Clinic Bipolar Disorder Bioban

SUBMITTER: Trevino-Alvarez AM 

PROVIDER: S-EPMC12569603 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature