Discovery of Unprecedented Arylation Coupling Cyclopeptide Inspires Natural Product-like Antitubercular Lead Compounds.

ABSTRACT: Tuberculosis (TB) remains one of the world's deadliest communicable diseases. Naturally derived antibiotics appear frequently in nature as collections of structurally similar compounds representing an adaptive evolutionary response to drug resistance development. Herein, we report an undescribed versicomycin (1), featuring an unprecedented post-nonribosomal peptide synthetase (NRPS) assembly line-modified skeleton, which was isolated from the marine-derived fungus. Gram-scale total synthesis of versicomycin (1) was accomplished using a hybrid synthesis strategy combining solid-phase chemistry, solution-phase cyclization, and chemical C-H bond functionalization. Inspired by this undescribed natural product (NP) skeleton, we efficiently developed a compound library comprising 8

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC12569659 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature