Stoichiometry-Controlled Structural Transformation of Diphenylalanine Nanoassemblies through Coassembly with Charged Dipeptides.

ABSTRACT: Peptide self-assembly produces a wide range of well-structured nanostructures, offering significant potential for biomedical and nanotechnological applications. However, controlling the morphologies of these assemblies is considerably challenging due to their intricate polymorphisms and complex responsiveness to environmental changes. In this study, we present a stoichiometry-controlled strategy to finely tune the morphology of supramolecular nanostructures by coassembling diphenylalanine (FF) with charged aromatic dipeptides. Diverse nanostructures including one-dimensional nanotubes, two-dimensional planar sheets, and three-dimensional nanovesicles are obtained by varying the ratio of two peptide building blocks. These structures are predicted by coarse-grained simulations, subsequently

SUBMITTER: Tang Y 

PROVIDER: S-EPMC12569661 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature