Development of a Direct Sampling Module for Compact Capillary Liquid Chromatography.

ABSTRACT: The automation of reaction monitoring analysis can greatly improve the capability to obtain real-time feedback on reaction progress and aid in method optimization. Liquid chromatography (LC) is a widely used analytical technique for organic reaction monitoring, but the large size of the instrumentation can make online analysis difficult and impractical. Compact and miniaturized LC instrumentation provides the opportunity to simplify the process of analyzing samples at the reaction site, but the smaller scale of capillary LC columns is often incompatible with commercial reaction sampling systems designed to work with larger volumes. Here, a compact sampling module (CSM) designed to automate sample collection from a variety of reaction devices with volumes that are compatible with capillary

SUBMITTER: Doupsas N 

PROVIDER: S-EPMC12569728 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature